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Symbol
Name
ID

Unc13a
unc-13 homolog A
MGI:3051532

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Dysphagia

Spasticity

Fatigable weakness of bulbar muscles

Fatigable weakness of swallowing muscles

Fatigable weakness of respiratory muscles

Motor neuron atrophy

Amyotrophic lateral sclerosis

Neurodegeneration

Fasciculations

Paralysis

Babinski sign

Dysarthria

Language impairment

Depression

Emotional lability

Anxiety

Atypical behavior

Agitation

Cognitive impairment

Frontotemporal dementia

Sleep abnormality

Hyperreflexia

Jaw hyperreflexia

Disease(s) Associated with UNC13A

amyotrophic lateral sclerosis

Mouse Phenotypes		nervous system phenotype	abnormal synaptic vesicle morphology	abnormal synaptic vesicle number	abnormal neuron physiology	abnormal synaptic vesicle recycling	abnormal CNS synaptic transmission	abnormal excitatory postsynaptic currents	decreased synaptic depression	decreased neurotransmitter release
Availability	Mouse Genotype	nervous system phenotype	abnormal synaptic vesicle morphology	abnormal synaptic vesicle number	abnormal neuron physiology	abnormal synaptic vesicle recycling	abnormal CNS synaptic transmission	abnormal excitatory postsynaptic currents	decreased synaptic depression	decreased neurotransmitter release
	Unc13a^tm1Bros/Unc13a^tm1Bros	*
	Unc13a^tm2Bros/Unc13a^tm2Bros
	Unc13a^tm3Bros/Unc13a^tm3Bros	*
	Unc13a^tm4.1Bros/Unc13a^tm4.1Bros

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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